Juliet is up to no good. There's going to be a Goodwin story in the future, although it's hard to determine if they are joking. Rachel may not have had the cancer come back... Ben's folder may have been a lie, MAY.
Let's just say the end of the season features a showdown between Jack and Locke — a showdown long anticipated and a showdown with an extremely significant outcome for the future of the castaways.
I hear we're going to meet Ben's mommy and daddy. We will get much more info about Ben's origins and the origins of the island
We will see Dharma before the purge and we might see how they repelled the smoke monster with the sonic fence
I'm told there will be at least five deaths on Lost during the month of May