Just a few nuggets of goodness....
The sixth season will begin with an examination of what happened after Juliet seemingly detonated the hydrogen bomb. As usual, [Matthew] Fox said, "It's very surprising and probably fairly confusing initially to the audience." Source: Kristin on E!Online
Team Darlton is checking the availability of several MVPs [from past seasons to appear in the series final season. ...] After sitting out last season, [Emilie] de Ravin will return as a full-time series regular for Lost's sixth and final season, Team Darlton confirms. "Damon and I are very excited to bring Claire back to the show," says Carlton Cuse, "and even more excited for people to experience just how she will return." Source: The Ausiello Files
"Like, a third of the way in to the season, I would guess we are going to settle into one time frame, and it will be very linear-no more flashbacks, nothing. It will be on the Island and sort of a final conflict to the end," said [Matthew] Fox. He assured fans that all the crazy storylines introduced in earlier seasons will be resolved and that the conflict between Jack and Locke "will come head to head" this season, but he wouldn't divulge more than that. When asked what would happen if he did, he said, "Some guys would pull up outside this building in a white van and masks, and I'd never be seen again." Source: Kristin on E!Online
Lost masterminds Damon Lindelof and Carlton Cuse have been dropping hints about how the show will end next spring. Among the mysteries unravelled in the very last episode will be the significance of the four-toed statue, what the Smoke Monster really is and who the skeletons in the cave were. [...] Says Cuse: "The end of the show will be a combination of trying to answer mysteries the audience still cares about, such as the statue and the Smoke Monster. We'll also be answering the skeletons in the cave question. We will answer the questions we feel are important and central to the plot. At the same time we will be trying to tell redemption stories about the characters. These characters do indeed have a destiny." Source: Sunday Mercury